Scientists develop breakthrough vaccine against cegps chip amazonrvical cancer10 Reasons Why The Oxjam Music Festival Is Using An 03 Phone Number Oklahoma City"s favorite local rock band will be reuniting with their original line-up, with lead singer Kellen McGugan. It has been over a year since the original members of PBC were rocking all over Oklahoma City, and concert goers are anxious to see what they have in store. Tell them all about the AVON opportunity and how it"s only $10 to join and how they get 50% off their first 4 orders and a good percentage off their following orders. Show them how they can not only save hundreds of dollars off their own orders but how they can earn more selling to family and friends. While you may lose that every campaign in sales you will gain that much in your sport wristbands leadership bonus! Saturday"s festival is geared toward the whole family, and admission is free for all. "Celebrate Downtown, C"Mon" will be held at 5th & Maine in downtown Tulsa. Musical talent will include Mary Cogan, Rochelle Chambers, David Skinner Band, WallStreet, Eldredge Jackson, and Jeff Shadley Group. Holding a raffle is also a great way to get new recruits. Simply offer a gift basket, full size item or even a gift certificate. On the raffle entry form provide a place for their name, address, phone number, and whether or not they have an AVON Representative and if they would like more information on receiving their items at a discount, and if they would like more information on becoming an AVON Representative for only $10. Off Broadway is one of the few St. Louis music venues that attracts indie rock and punk bands that are up and coming, but that aren"t completely obscure. A perfect example is the brand new psychedelic folk group Here We Go Magic, which played a beautiful set at Off Broadway a couple weeks ago. The band had stopped in St. Louis on it"s way to the festival wristbands, where they played a ton of shows that got pretty impressive reviews. And the gun slingin", whiskey guzzlin" indie rockers Murder By Death are scheduled to play at Off Broadway in May - it"s bound to be a more appropriate atmosphere than if the group performed at the Pageant to the tune of $5 Budweisers. It is common for hosts to choose a theme based upon the time of year such as children"s clothing for back-to-school and toys for Christmas, or upon the needs of their family. Since the point of the party is to keep costs down, it is important to not go crazy with refreshments or decorations. When having a Swap Party, it is acceptable to do potluck if you want food at it. For some, it is more of a "get in and get out" event wristbands where items are put out for the taking, and as choices are made, people leave with their "new" items. At this second President Bush just finished his last official press conference as POTUS. He started out the presser with a conciliatory and reflective tone, but as I watched the presser progress, one could see a change taking place. The first question from the reporters was if he thought he"d made any mistakes. It just went downhill from there. The Final Destination: Rated R for strong violent/gruesome accidents, language and a scene of sexuality. The fourth film in the series has a teenager avoiding death at a racetrack. Like those before him, he learns the hard way that death will not be jilted. The director and writer behind the second Final Destination are reunited for this installment.
Chinese researchers have taken a major step forward in developing a new-generation vaccine that has the potential to protect against almost all of the most potentially lethal forms of human papilloma virus (HPV).
HPV is primarily transmitted through sexual contact. More than 200 distinct HPV types have been identified, of which at least 18 are high-risk types associated with 99 percent of cervical cancers, the second most common cancer among women, after breast cancer.
Gardasil 9 is the current market-available HPV vaccine providing the broadest protection against infection from nine HPV types, seven of which can cause 90 percent of cervical cancers.
However, it remains unclear whether widespread immunization with vaccines like Gardasil 9 could lead to an increase in infection rates from the other cancer-related HPV types, responsible for the remaining 10 percent of cervical cancers.
To expand type coverage, the approach used in previous-generation vaccines was to increase the number of virus-like particles. One particle resembles one HPV type, and it can elicit immunity to one HPV type. The more particles a vaccine has, the broader protection it provides.
However, this approach is fraught with difficulties, as an increase in type coverage will dramatically enhance protein amounts and immunological agent levels per dose, which will cause side effects, such as pain, swelling and fever, and raise the manufacturing complexity and production costs.
Researchers at Xiamen University, in east China"s Fujian Province, have developed a highly effective vaccine candidate that can protect against more HPV types with fewer particles.
They divided 20 major HPV types, including HPV6 and HPV11, which accounts for 90 percent of genital warts, into seven groups based on genetic relationships, and found that genetically close HPV types shared high structural similarities.
Xia Ningshao, lead researcher, compared the virus or the vaccine to a "ball". All HPV types are similar in appearance, but are significantly different in the surface of the "ball", such as veins, convex and concave areas. These structural features on the surface are called loops.
"Because of the loops, one type of vaccine can stimulate the production of antibodies only against the infection of one type of virus, and is unable to prevent the infection of other types," he said.
Using a loop swapping approach, researchers engineered a complex virus-like particle with the loops of three genetically close HPV types: HPV33, HPV58 and HPV52.
They tested the triple-type particle in experiments on mice and monkeys, and found it could provide high immune potency comparable with a combination of three virus-like particles.
The new approach was equally successful in developing another four triple-type particles using the other 12 major HPV types.
"The research paves the way for an improved HPV vaccine made of seven-type virus-like particles to protect against as many as 20 HPV types," said Xia.
The results were recently published in the international Nature Communications journal. Reviewers said the new-generation vaccine candidate was "a remarkable achievement" for having broader type coverage, lower cost and lower amounts of proteins and agents, and "will be moved forward into a clinical trial."
Three HPV vaccines have been introduced to China, covering two, four and nine types. The three-shot HPV vaccination covering nine types is priced for 3,894 yuan. In some areas, scalpers sell it for over 6,000 yuan, which is prohibitive for many poor women.
Researchers say the new-generation vaccine candidate will be available for women aged 9 to 45. Its cost will not exceed the current market-available vaccines.
Two HPV vaccines previously developed by the Xiamen University have reached the clinical test stage and are expected to enter the market in 2019 and 2022.
The world"s first HPV vaccine, Gardasil, was developed by Chinese cancer researcher Zhou Jian and Australian immunologist Ian Frazer. In 1995, Zhou and Frazer started cooperating with Merck and Co. to develop the vaccine. After Zhou"s sudden death from hepatitis in 1999, Frazer continued the work until the vaccine was ready for market.
According to the World Health Organization, about 570,000 new cases and 311,000 deaths of cervical cancer are reported worldwide every year. China has a very high incidence and death rate, with 106,000 new cases reported and about 48,000 deaths in 2018.
Cervical cancer can be fatal. HPV vaccination has been promoted in China in recent years. Women are also advised to prevent the disease through regular health checks.go wristbands hen party wristbands support bracelets the wristband factory glastonbury wristband